Hey Ben, good luck with the build. I'm contemplating another "heavy lifter" myself but we all run into the same questions.
ESC's/PDB Herkules III is the way to go if you ask me.
FC: I'm waiting for Synapse, I've been speaking with the lead developer and it looks like the release is coming up at NAB (ssshhhh). I want the first one.. MK is rock solid but a little bit of a learning curve and DJI well, you could go with A2. I hear great things about it but if you follow DJI the price will likely drop quite a bit in the next few months. I spent $20k building an S800 a little over a year ago and can get the same setup now for $6500...
Batteries: depends on the environment. Less windy days I go with a 4S on 15" prop for more flight time but for heavy wind 6S on 12" on my Y6
View attachment 20452
Props: I love the TMotors, been flying them for awhile now and other than wood I'd say they
are the best out there.
Frame: I'm keeping my eye on the Gryphon Dynamics frames, they are strong yet break down easily. If they are good enough for the kopterworx X8 Hammer 20kg lifter they are good enough for me. Quadrocopter carries the line in the US if they ever get any stock. I like the Sky Hero frames too, we have a 750mm Spy Y6 and a 850mm Spyder X8 on it's way. They break down quick and can take a beating.
Motors: Your call, the UPower series looks good but I like the shaft size on the Avrotos. They just seem to be built stronger.
Anyway, that's my 2 cents. I'll keep an eye on this thread to see how it goes, best of luck! All and all I keep leaning towards the boys over at Kopterworx. I'm going to pay them a visit in the next few months. The gear is expensive but if you follow what's happening with FAA and in my case TC all commercially used UAV's UAS's will need to be certified by the manufacturer and KW has been the only company (oh wait there is also heliguy.com) that are doing builds in EU that are being certified by the CAA. If you are lining up for future commercial use (and I know you are) it's worth a little research. Spend a little more now, save a lot more later.
That said, and I know we aren't talking quads I'm really liking my RECON ($3500) for it's 30+ minute flight time with NEX7. 60+ minute with gopro. It handles great in the wind and fly's like a disco. I see steadydrone has recently released the Qu4d X boasting a 60min flight time as well but it's $15000 base.
Fly Safe!
Jason