Actually, it's been mentioned more times than I care to remember.
Run your vtx and camera off a seperate battery, never off the main pack. This wouldn't suprise me at all if it clears up a ton of your problems. Right now, if your vtx and or camera is powered up by the main battery you are probably swamping the hell out of your system.
Always, always keep systems seperated, especially your fc system.
Keep the vtx as far away from other components, they are noisey as a kid in the dentist chair! If you can, get a piece of cf and keep it inbetween the vtx and the rest of the components. This will block any noise from going where it shouldn't.
Twist all your wires, this will help with reducing noise, also. Remember, it's all accumulative.
Your gps should be as far away as possible, also.
Keep your wires, low and high voltage seperated. Don't allow any to overlap the others.
Secure anything that is loose and can bounce or vibrate.
Props need to be balanced to a fine tee, both the blades and the hubs. This is really easy to do, but time consumming, and it has to be done.
As far as gains go, basic gains on a 550 size will run around 130-170ish. This all varies every time, even if you have 2 identical platforms.
Read the manual over and over and over again, until you have it firmly fixed in your head, especially the LED codes!
The whole battery/prop thing is pretty much true, it's all a balancing act. Going 4s is great, less amp's consummed, but remeber you will be flying with more weight, unless you lower the capacity to equal weigh out, but this means less flight time.
It's all about experimentation to discover what works for you best, but right now your a long way from that point.
Go back thru your entire set-up, paying particular attention to what I described above. Then report back your findings. I think you'll be happy you did.
99% of the time, all problems will be operator related, not the DJI. Sure, it happens, but damn near every time it's something you did or didn't do right.