Yes, I always have alternating CW and CCW in one plane and CW CCW on one arm. This is of course independent on the FC. Here an X12 with a KK-board:
before it was a Naza:
The only point on my X16s is, that the FC needs to be able to be placed far off the center (important for ACC and GPS), like the WKM can be. If you only intend to use the rate-mode (manual mode) so gyros only, every FC can do that. The bigger the copter, the less work for the FC.
You can also fly an X8 as a quad ( + quad for the FC) following that principle.
I will post my results on the payload (with video), if I would mention it before there possibly would be discussions, but this copter is more towards lifting the operator with the cam than the cam only. And no, there is no cam planned on this copter, also the copter was not planned for a cam. Possibly it will just become a 1:5 millenium falcon.
These are only the first testing moves.
Yet another picture:
best regards
Ferdinand