Unlike pretty much all the other Flight Control options, DJI actually provides a pretty comprehensive Manual (or Quick Guide) with every new software release. DJI may commit a whole swathe of sins but the effort they make with the Manual is to be applauded.
However, there are one or two really confusing parts. One is their method of explaining what values to enter with regard to the GPS, IMU and Centre of gravity and another is the Voltage protection values. The new A2 Manual still has the same confusing GPS, IMU etc. instructions illustration but it has changed the Voltage Protection setup for something much simpler.
Getting back to your post, you have confused the voltage sag difference between a battery not under load and when under load in flight and the voltage drop difference between a fresh LiPo and the same battery after several minutes of flight. If the total initial, unloaded voltage is 22.5v and the the inflight voltage immediately after take off is 21.8v, the voltage sag is 0.7v. THAT is the the middle figure.
So, enter 22.5v in the first field and 0.7v in the second field and the WKM will calculate the last value.
The second area of confusion is what value to set as the 'unloaded' second level protection. They do not give a sensible guide on this. Personally, I work backwards with this one. I will calculate the final limit by, for example, multiplying 3.6v by 6 cells = 21.6v, and adding the 0.7v sag figure, arriving at at 22.3v as the initial Second Level value.
LiPo's will have different levels of voltage sag under load according to their condition and age so the whole thing is always going to be approximate.
I have the voltage protection activated, audible alarms on each pack, the transmitter Timer is set and I also have the iOSD. To disregard the Voltage Protection and leave it switched off completely is to lose the facility of the automatic Return To Home if there is a battery cell problem when the MR is too far away to hear the audible alarm. As for using the OSD information, I do not believe I ever look at that information when I am flying, I am too occupied concentrating on flying and framing. Personally, I do not recommend switching off the Voltage Protection. I tend to rely upon the Tx Timer as my primary signal to tell me when to start thinking about coming home.