... please do not forget in your considerations, that in risk management, there is only the question "When"/"How often", not "If". So of course some regulations will improve the safety and some wont, and here we are talking about probabilities. Vehicles that fly fail, like every other vehicle, only that in case of flying, failure means crash. If the flight is over populated areas the probability is higher (which can be quantified) to hit someone, than in spare or unpopulated areas. It is also not a matter of size (Hubsan or Airliner), just a matter of damage they can do. So whatever (new) method or technology can provide safety it will fail, out of each failure we can learn and improve, but it will fail again. Even if you think, that you are so professional, and followed all guides and rules, the vehicle will fail, and you should be prepared for the day this happens.
If you need some prove of evidence just look at the news, there have been unsinkable ships and invulnerable nuclear power plants, lost airliners, .... and it always was some "unfortunate series of evens". Not what you have thought about will take you down, it is what you have not thought about (beside the standard errors).
Another rule for flying machines is "weight kills", so what ever clever idea you had on how to do this or that, always have the added weight in mind.
best regards
Ferdinand