HUGE difference. At least for me. I was flying the 3 blades on a rig that weighed 16 lbs and it was fine, on my 22b X8 on an A2 it was un flyable (almost) the props were bending and the motors were working almost 25% harder than when we strapped T-motor CF 2 blade props on them. @Hexacrafter can weigh in as well, we were puzzled at why the rig was behaving so badly, we switched props and it was a new machine.
If anyone wants to try the 3 blades I have a set for an X8 and a set for a Y6/Hex... make you some killer deals!
I'm intersted. Got a quad I'd like to test them on.